Peer-Reviewed Papers
Planaria
Shreesha, L., and Levin, M. (2023), Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model, Entropy, 25(1), 131, doi:10.3390/e25010131
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Cervera, J., Manzanares, J. A., Levin, M., and Mafe, S. (2022), Transplantation of fragments from different planaria: a bioelectrical model for head regeneration, Journal of Theoretical Biology, 558: 111356
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Grodstein, J., and Levin, M. (2022), A Computational Approach to Explaining Bioelectrically-induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration,
Bioelectricity, 4(1): 18-30
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Bischof, J., Day, M., Miller, K., LaPalme, J., and Levin, M. (2020),
Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria,
Developmental Biology, 467 (1-2): 51-65
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Williams, K., Bischof, J., Lee, F., Miller, K., LaPalme, J., Wolfe, B., and Levin, M. (2020),
Regulation of axial and head patterning during planarian regeneration by a commensal bacterium, Mechanisms of Development, 163: 103614
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Fields, C., and Levin, M. (2020), Does regeneration recapitulate phylogeny?, Communicative & Integrative Biology, 13(1): 27-38
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Cervera, J., Meseguer, S., Levin, M., and Mafe, S. (2020), Bioelectrical model of head-tail patterning
based on cell ion channels and intercellular gap junctions, Bioelectrochemistry, 132: 107410
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Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J.,
Davidian, D., Morokuma, J., and Levin, M. (2019),
Regenerative Adaptation To Electrochemical Perturbation In Planaria: A Molecular Analysis
Of Physiological Plasticity, iScience, 22: 147-165
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Beane, W. S., Adams, D. S., Morokuma, J., and Levin, M. (2019), Live Imaging of Intracellular pH
in Planarians Using the Ratiometric Fluorescent Dye SNARF-5F-AM,
Biology Methods and Protocols, 4(1): bpz005
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Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M. (2019), Neural control of body-plan axis in regenerating planaria,
PLOS Computational Biology, 15(4): e1006904
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Ferenc, N. N., and Levin, M. (2019), Effects of ivermectin exposure on regeneration of
D. dorotocephala planaria: exploiting human-approved ion channel drugs as morphoceuticals, Macromolecular Bioscience, 19(3): 1800237
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Levin, M., Pietak, A., and Bischof, J. (2019), Planarian Regeneration as a Model of Anatomical
Homeostasis: Recent Progress in Biophysical and Computational Approaches, Seminars in Cell and Developmental Biology, 87: 125-144
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Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M. (2019), The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity, Biophysical Journal, 116(5): 948-961
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Lee, F. J., Williams, K. B., Levin, M., and Wolfe, B. E. (2018), The bacterial metabolite indole inhibits regeneration of the planarian flatworm Dugesia japonica, iScience, 10: 135-148
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Ferreira, G.B.S., Scheutz, M., and Levin, M. (2018), Modeling Cell Migration in a Simulated
Bioelectrical Signaling Network for Anatomical Regeneration, in Takashi Ikegami, N.V., Olaf
Witkowski, Mizuki Oka, Reiji Suzuki and Hiroyuki Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, pp. 194-201
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Pietak, A., and Levin, M. (2018), Bioelectrical control of positional information in
development and regeneration: a review of conceptual and computational advances,
Progress in Biophysics and Molecular Biology, 137: 52-68
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Fields, C., and Levin, M. (2018), Are planaria individuals? What regenerative
biology is telling us about the nature of multicellularity, Evolutionary Biology,
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Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M. (2017),
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous
Bioelectric Gradients, Biophysical Journal, 112(10): 2231-2243
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Levin, M., Morokuma, J., and Finkelstein, J. (2017), Space travel has effects on planarian regeneration that cannot be explained by a null hypothesis, Regeneration, 4(4): 156-158
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Morokuma, J., Durant, F. R., Williams, K. B., Finkelstein, J. M., Blackiston,
D. J., Clements, T., Reed, D. W., Roberts, M., Jain, M., Kimel, K., Trayger, S. A.,
Wolfe, B. E., and Levin, M. (2017), Planarian regeneration in space: persistent anatomical,
behavioral, and bacteriological changes induced by space travel, Regeneration, 4(2): 85-102
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Lobo, D., and Levin, M. (2017), Computing a worm: reverse-engineering planarian regeneration, in Adamatzky, A. (Ed), Advances in Unconventional Computing. Emergence, Complexity and Computation, vol 23, Springer: Cham, pp. 637-654
Neuhof, M., Levin, M., and Rechavi, O. (2016), Vertically and horizontally-transmitted memories - the fading boundaries between regeneration and inheritance in planaria, Biology Open, 5(9): 1177-1188
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Sullivan, K. G., Emmons-Bell, M., and Levin, M. (2016), Physiological Inputs Regulate
Species-Specific Anatomy During Embryogenesis And Regeneration, Communicative & Integrative Biology, 9(4): e1192733
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Lobo, D., Morokuma, J., and Levin, M. (2016), Computational discovery and in vivo validation of
hnf4 as a regulatory gene in planarian re-generation,
Bioinformatics, 32(17): 2681-2685
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Durant, F., Lobo, D., Hammelman, J., and Levin, M. (2016), Physiological controls of
large-scale patterning in planarian regeneration: a molecular and computational
perspective on growth and form, Regeneration, 3(2): 78-102
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Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M. (2015), Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia
dorotocephala flatworms, International Journal of Molecular Sciences, 16(11): 27865-27896
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Lobo, D., and Levin, M. (2015), Inferring regulatory networks from experimental morphological phenotypes:
a computational method reverse-engineers planarian regeneration, PLoS Computational Biology, 11(6): e1004295
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Shomrat, T., and Levin, M. (2013), An
automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration,
Journal of Experimental Biology, 216(20): 3799-3810
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Overview
Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M. (2013),
Bioelectric signaling regulates head and organ size during planarian regeneration,
Development, 140(2): 313-322
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Lobo, D., Malone, T. J., and Levin, M. (2013), Towards
a bioinformatics of patterning: a computational approach to
understanding regulative morphogenesis, Biology Open, 2(2): 156-169
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Lobo, D., Beane, W., and Levin, M. (2012), Modeling planarian
regeneration: a primer for reverse-engineering the worm,
PLoS Computational Biology, 8(4): e1002481
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Beane, W. S., Tseng, A.-S., Morokuma, J. M., Lemire, J. M., and
Levin, M. (2012), Inhibition of
planar cell polarity extends neural growth during regeneration, homeostasis,
and development, Stem Cells and Development, 21(12):
2085-2094
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Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M. (2011),
A chemical genetics approach reveals H,K-ATPase-mediated
membrane voltage is required for planarian head regeneration,
Chemistry & Biology,
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Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M. (2010), A second-generation device for automated
training and quantitative behavior analyses of molecularly-tractable model organisms, PLoS One, 5(12): e14370
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Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J. M., Hwang, J. S., Gojobori, T., and Levin, M. (2010), Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration, Developmental Biology, 339(1): 188-199
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Oviedo, N. J., Pearson, B. J., Levin, M., and Alvarado, A. S. (2008), Planarian PTEN homologs regulate stem cells and regeneration through TOR
signaling, Disease Models and Mechanisms, 1(2-3): 131-143
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Live imaging of planarian membrane potential using DiBAC4(3),
Cold Spring Harbor Protocols, 3(10): pdb.prot5055
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Gene knockdown in planarians using RNA interference, Cold Spring Harbor Protocols, 3(10): pdb.prot5054
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Establishing and maintaining a colony of planarians, Cold Spring Harbor Protocols, 3(10): pdb.prot5053
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Oviedo, N., and Levin, M. (2008), The planarian regeneration model as a context for the study of drug effects and mechanisms, in R. B. Raffa & S.M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 95-104
Nicolas, C.L., Abramson, C.I., and Levin, M. (2008), Analysis of behavior in the planarian model, in R. B. Raffa & S. M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 83-94
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior, Cold Spring Harbor Protocols, 3(10): pdb.em0101
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Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008),
Planarians: a versatile and powerful model system for molecular
studies of regeneration, adult stem cell regulation, aging, and behavior,
in Emerging Model Organisms: A Laboratory Manual, Volume 1, Cold Spring Harbor Press: Cold Spring Harbor, NY
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Hicks, C., Sorocco, D., and Levin, M. (2006), Automated Analysis of Behavior: A Computer-Controlled System for Drug Screening and the Investigation of Learning, Journal of Neurobiology, 66(9): 977-990
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Nogi, T., Yuan, Y. E., Sorocco, D., Perez-Tomas, R., and Levin, M. (2005), Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica, Laterality, 10(3): 193-205
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Nogi, T., and Levin, M. (2005), Characterization of innexin gene
expression and functional roles of gap-junctional communication in planarian
regeneration, Developmental Biology, 287(2): 314-335
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